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But the major limitation of the use of flavonoids is the adverse effects associated with their consumption in high doses, including necroptosis, apoptosis, cardiac dysfunction, and neurotoxic side effect (Satari et al., 2021)

10.1016/j.fitote.2014.05.010 207 WangL.XuN.ZhangJ.ZhaoH.LinL.JiaS.et al (2015)

The reduced activity of the signal molecule AI-2 at a later stage may be related to the unstable and easily decomposed character of the signal molecule AI-2 (Chen et al., 2002)

Whether SARS-CoV-2 nAbs decline at a similar pace is yet to be conclusively established

CMS121 has completed IND-enabling studies, and J147 has entered Phase 1 clinical trials, underscoring their pathway-driven therapeutic promise (Maher et al., 2020