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Twelve-week old female C57/BL6J mice were individually housed in specific pathogen-free conditions with sterile ventilator cages containing corn bedding, with ad libitum access to chow and water

Small molecular kinase inhibitors can block phosphorylation of the catalytic domain in the receptor by competitive or non-competitive antagonism of the ATP binding site, thereby preventing the recruitment of signal transducers and mediators, and thus impeding the transmission of downstream signals (Munshi et al., 2010

For example, curcumin has been reported to prevent diabetic retinopathy through its hypoglycemic, antioxidant, and anti-inflammatory mechanisms (Gupta et al., 2011

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Based on iron overload observed in the brain tissue of TBI patients, removal of excess iron could be an effective strategy to improve their prognosis