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For example, LA is metabolized by LOX into hydroxy-octadecene dienoic acid (HODEs) derivatives (such as 9- and 13-HODE) and is further converted into oxygen-HODE (such as 9-oxygen-HODE and 13-oxygen-HODE) and epoxy-HODE, which play a role in inflammation (30)

Rights and permissions About this article Cite this article Sidiq, S., Kumar, R.R., Passi, N.D

To be modifiable, the Cys must have a low pKa, a property that is largely determined by the electrostatic environment of the protein context

Modifying ligands can enhance receptor-ligand interactions between NPTAs and the BBB surface, hence promoting the penetration of NPTAs through the BBB [74]

It leaves a linear scar, typically concealed by surrounding hair