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Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions

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This liberates starch and nutrients, facilitating microbial fermentation (Emperaire, 2023)

Among over 20 distinct RCD modalities reported, ferroptosis, described as a ROS-dependent non-apoptotic iron-driven cell death [496], has attracted considerable attention as a potential therapeutic target in cancer [497]