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From this aspect, the pathogens would be able to enter cells of neuronal tissue as a function of the patients APOE 4 positive genetic status contributing to their overall virulence

Importantly, trimetazidines main mechanism of action in boosting mitochondrial energy generation when mitochondrial function is impaired dovetails with previous research highlighting bipolar depression as a state of decreased mitochondrial energy generation [20,21,22,23,24,25]