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ResAM showed overall an increased expression of genes associated with canonical AM processes, such as fatty acid and lipid metabolism, PPAR signaling, phagocytosis, apoptotic cell clearance and lysosomal markers ( Olr1, Fabp4, Fabp1, Abcg1, Lpl, Lipa, Mgll, Naaa, Marco, Cd36, Axl, Mertk, Lamp1, Scarb2, Ctsd ) ( Figures 5A, B )

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In the meantime, people who in the past have not been associated with the exercise of much direct power in American life (statisticians, cancer scientists, public-interest lawyers, teachers, public-service advertising men) and a small number of senators, their staff people, and some conscientious public servants in regulatory or other agencies, persevering through years of discouragement, have slowly but tellingly gathered momentum