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MECHANISM OF LOCAL ANESTHETIC TOXICITY Local anesthetics are generally safe and effective when limited to the site of therapy, such as tissue infiltration, near a nerve or a plexus of nerves

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As shown in Fig 1F, SOX2 + cells selfrenew and produce differentiated acinar cells marked by AQP5 and MUC19 but not KRT8 + duct cells after 14 or 30 days (Figs 1F and EV1E)