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Regarding the prenatal period, a significant RCT involving pregnant women positive for anti-thyroid peroxidase antibody (TPOAb), demonstrated that selenium supplementation led to a notable reduction in TPOAb levels during and after pregnancy [20,33]

As epigenetic marks, histone modifications, such as acetylation, methylation, phosphorylation, and ubiquitination, can be inherited and are essential for recruiting or activating downstream effectors (Liu and Si, 2024)

However, this is unlikely to uncover higher levels of toxicity than predicted here, as infants have lower hepatic enzymatic activity than adults 19,21,22,30 , leading to lower production of haemolytic metabolites compared to adults or older children

doi: 10.1007/s11306-024-02184-1, 118