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Recruitment was selective for those reporting adverse allergic reaction to aspartame-containing products, which affected the sample size, despite widespread recruitment over 4 years.] In a combined single-blind, double-blind, placebo-controlled study ( n = 12), the capacity of aspartame to reproduce the historically reported hypersensitivity reaction, allergic response (indicated by a positive skin test result), or a decrease in lung function was investigated

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10.1038/s41598-018-35890-7 144 ValentiD.de BariL.de RasmoD.SignorileA.Henrion-CaudeA.ContestabileA.et al (2016)

168 Another study showed tailor-made notched music training promoted normalization of brain activity that had been altered by tinnitus