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The free CDDP treatment group exhibited fluorescence intensity 5.4 and 11.0 times higher than the combined Cur + CDDP and CDCZA-treated group, respectively, indicating the effective depletion of GSH in Eca-109 cancer cells by CDCZA nanoparticles

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Conversely, animal models have also established that low levels of histamine-induced depression-like behavior, decreased locomotor activity in the home cage, and impaired aversive memory, leading to a decrease in wakefulness as well [185]