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Dihexa works by binding to the HGF receptor c-Met on hippocampal neurons, activating intracellular signaling pathways that increase synaptogenesis, dendritic spine density, and NMDA receptor expression

For a comprehensive overview of how peptides compare across tissue systems, our joint and tendon peptide research guide provides useful context

doi:10.1124/jpet.109.159939

Proteins in Rapid decrease-rapid increase group, accounting for 7% of the determined proteins, were primarily involved in cell adhesion and extracellular structure organization