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As a mitigation strategy, if the test for period effect post unblinding was significant, then the statistical model for the primary outcome had to be recomputed only on the data from the first period of the trial (where period effect is taken out)as recommended by clinical practice (3537)

Treatment is usually recommended for all individuals with the condition, regardless of symptoms

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Carcinogenesis 31(2):222-7, 2010

Research Applications Obesity and body weight regulation research Type 2 diabetes and glycemic control studies Appetite and satiety pathway research Amylin and GLP-1 receptor signaling studies Gastric emptying and postprandial glucose research Combination peptide pharmacology studies Energy intake and food reward research Cardiometabolic risk factor studies Hypothalamic appetite circuit research Comparative metabolic peptide studies Safety Profile The safety profile of the cagrilintide + semaglutide blend draws on the substantial individual safety datasets for each peptide as well as growing combination data from Phase 1b and Phase 2 clinical research