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Furthermore, over 90% of anal cancers are HPV-induced and more common in women than men (Cohen et al., 2019)

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In an in vivo model, it showed the potential to arrest the cell cycle, suppress mitosis in tumor, endorse apoptosis, down-regulate pro-survival transcription factors (survivin, Bcl-2, phospho-Akt, c-Myc, mTOR, EGFR, and VEGF), and increase p21/WAF1 activation [230]