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Overall, these mechanisms stunt cell proliferation, alter metabolism and gene expression patterns and induce high levels of ROS production, maintaining the cellular senescent phenotype

( Figure 2A ) (Tonkin et al., 2013

Copper storage and transportation Copper absorbed by intestinal epithelial cells via the transporter Ctr1 is guided by the copper chaperone Atox1 to ATPase copper transporter 7A (ATP7A) (23)

Interestingly, lactylation of NUSAP1 at lysine 34 prevents its protein degradation and increases its expression in PDAC cells, establishing an NUSAP1-LDHA-glycolysis-lactate loop that promotes PDAC metastasis