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The strengths of this study include the large population-based sample, the long follow-up period, the comprehensive approach to investigating genetic risk, the novel investigation of interactions, the careful adjustment for potential confounders, and the use of sensitivity analyses to investigate the robustness of findings

The use of tobacco stretched across the empire, through its social fabric, and across its cultural divides, a democratic dependency that still allowed differentiation of status with brands, accessories, and styles of consumption

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