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Zonulin family peptide (zonulin), a potent regulator for intestinal tight junctions, is highly expressed in autoimmune mice and humans and can be used to predict transition from autoimmunity to inflammatory arthritis

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Furthermore, one must investigate the associations between peripheral NIMETOX pathways and microglial activation A1 astroglial phenotypes via breakdown of the BBB and how these pathways may contribute to heightened neurotoxicity and subsequent neuronal damage within the CNS