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Long-term l-carnitine supplementation has demonstrated positive support for cardiovascular health after a 3-year follow-up in adult subjects

(Waldner 2006) A double-blind RCT (n=30) in patients receiving high-dose interleukin-2 therapy reported a reduction in serious cardiac events (e.g., arrhythmias and acute heart failure) with L-carnitine use compared to no therapy, but the small sample size and heterogeneity of the cancer types limit generalizability

They find that for the efficacy of l-carnitine on fasting plasma glucose (FPG), 2 g/day l-carnitine is required for at least 36.1 weeks

Expert Rev Clin Pharmacol

Regulatory feedback mechanisms leading to an increase in the dietary absorption of LC, and/or de novo synthesis may take place to overcome the LC deficiency and reduce the loss by urinary excretion