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Administration of DTA (25 or 50 ng/g, 2 x, i.p.) to CCl 4 -injured Lrat YFP-Col1a1-DTR mice caused ablation of aHSCs within 24h in a dose dependent manner (60% to 90%, respectively), as shown by the disappearance of YFP + Desmin + cells, and downregulation of Col1a1, YFP, DTR, and Cre mRNA, and attenuation of liver fibrosis at 3 days

Lentz SR, Sobey CG, Piegors DJ, Bhopatkar MY, Faraci FM, Malinow MR, and Heistad DD (1996)

Kojicprevents melanin formation, and conditions skin so that freckles and dark spots gradually fade away, revealing clearer skin

After 12 days of cultivating spermatogenic cells in a collagen-based gel matrix, round spermatogonial cells were observed, indicating that spermatocytes could be induced to differentiate into putative spermatids in vitro [202]