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reported that the anti-HGF mAb ficlatuzumab significantly inhibited the c-MET activation and rescued the capacity of cetuximab to inhibit the phosphorylation of EGFR in cetuximab-resistant CRC cell lines LM1215, SW48, and DiFi ( Rilotumumab , a fully human anti-HGF mAb that neutralizes HGF-dependent c-MET signaling, has been investigated in phase Ib/II trial (NCT00788957) in combination with panitumumab in previously treated patients with KRAS-WT mCRC

doi: 10.1176/appi.ajp.2020.20091382 14

Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury

T1-P15 A new Plasmodium vivax reference genome for South American isolates Katlijn De Meulenaere 1,2 , Bart Cuypers 2 , Dionicia Gamboa 3,4 , Kris Laukens 2 , Anna Rosanas-Urgell 1 1 Department of Biomedical Sciences, Institute of Tropical Medicine Antwerp, Antwerp, Belgium

Donovan J (2015) Successful treatment of corticosteroid-resistant ophiasis-type alopecia areata (AA) with platelet-rich plasma (PRP)