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One RCT with 19 schizophrenia patients reported that controlled-release melatonin 2 mg significantly improved sleep efficiency compared to placebo [47]

Herxheimer reactions however continued the days on IV ceftriaxone, despite trying to pulse the IV medication 4 days in a row per week, so she was subsequently taken off this protocol, and switched to IV doxycycline 200 milligrams per day, infused over a 2 hour time period along with Plaquenil, nystatin, and rifampin 300 milligrams PO BID

Ethics declarations Conflict of interest The authors declare that there are not competing interest in this article