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This activation: Promotes directed cell migration toward injury sites Enhances cellular outgrowth from damaged tissue edges Improves cell survival during the stressful healing process Facilitates proper tissue organization This mechanism is particularly relevant for tendon and ligament healing, where cellular organization and proper fiber alignment are critical for functional recovery

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Am J Physiol Regul Integr Comp Physiol (2006) 291(4):R8804

Reactive oxygen species (ROS) levels were assessed by C11-BODIPY probe, oxidative stress indicators including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase were measured by kits, and Cytochrome C, Ferritin, mitochondrial transcription factor A (TFAM), glutathione peroxidase 4 (GPX4) and SLC7A5 expression were detected by Western blot