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This group developed 37.5% hepatotoxicity due to the anti-tuberculosis therapy, while the group supplemented with NAC maintained constant values of both enzymes, avoiding liver damage 35 ( Figure 5 )

The following table reflects the impact on resource use data generated using claims from the September 2022 update of the FY 2022 MedPAR file

Overall, drug repurposing leverages the multi-target potential of existing agents, expands the antifungal arsenal against resistant pathogens, and provides a theoretical foundation for developing combination therapy and novel antifungal strategies (Zhang et al., 2021)