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CRH acts via its G-protein coupled receptor to activate adenylate cyclase, increase intracellular cAMP and stimulate protein kinase-A (15)

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Endothelial cells are highly vulnerable to oxidative stress, and the excessive production of free radicals, alongside toxic byproducts of erythrolysis and iron overload, causes significant damage, leading to apoptosis and further compromise of the BBB

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Vitamin C is highly water-soluble