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It is essential for the catalytic activity of several classes of histone deacetylases (HDACs), as well as for the structural integrity and function of certain histone acetyltransferases, which together govern chromatin compaction and gene expression, and of DNA methyltransferases (DNMTs), which influence DNA methylation and processes such as lineage commitment and genomic imprinting 11

However, under conditions of overexpression, gene mutation, and Serine 129 phosphorylation, -syn aggregates abnormally and eventually forms neurotoxic oligomers, fibrils, and Lewy bodies [206, 207]

Glutathione is a tripeptide antioxidant produced naturally in cells, but many people explore supplementation to support oxidative stress management

Melatonin is a hormone our brains produce at night to regulate sleep-wake cycles, but it is also a potent antioxidant with roles in reproductive function

& Krum, H