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This multi-omics-driven organoid platform not only validates the effectiveness of drug targets but also predicts drug-metabolite interaction networks through metabolomics analysis, providing a theoretical basis for dose design in subsequent clinical trials (Zou et al., 2021), discovering that epigenetic regulatory factors (such as Histone Deacetylases) may become synergistic targets to enhance drug sensitivity (Ramaiah et al., 2021)

Seahorse assay For mitochondrial stress test, Agilent Seahorse XF Assays were performed in a 24-well XF Cell Culture Microplate using Seahorse XFe24 analyser (Agilent Technologies)

doi: 10.1242/dev.137075

Other areas involved in cognition such as the amygdala, prefrontal cortex can also be affected (Block et al., 2005

90 KempkeS.LuytenP.ClaesS.Van WambekeP.BekaertP.GoossensL.et al