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doi: 10.1189/jlb.3MR0316-106R 205 MaesMMihaylovaILeunisJC

The recent shift in perspective from viewing oxidants as merely damaging agents to key signaling molecules is an important one, and one which places GSH homeostasis as a central mediator of these communications

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147 Overexpression of miR-144-3p could downregulate the GSH/GSSG ratio, increase the levels of ROS, Fe 2+ , and ACSL4, promote ferroptosis and thus reduce the metastasis of osteosarcoma cells, while high expression of ZIB1 plays the opposite role, 147 indicating that miR-144-3p and its downstream ZIB1 are involved in the development and metastasis of osteosarcoma mainly by interfering with iron metabolism and redox homeostasis