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In fibromyalgia, oxidative stress has also been linked to pathophysiology (Cordero et al., 2010) with studies suggesting that antioxidant therapies may help reduce elevated pro-oxidative pathways such as lipid peroxidation and mitophagy (Assavarittirong et al., 2017) with melatonin being shown to improve brain function in the GWS model, through modulation of oxidative stress (Madhu et al., 2021)

Moreover, MO25 plays a key role in stabilizing the LKB1 activation loop in a conformation required for phosphorylation of substrates [79]

Nakao, T

Epub 2017 May 3 Roef, Greet L et al

however, as is the case with the mitochondria, a dysfunction of these systems in diseases or environmental toxicity generates ROS as a by-product