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However, GLS2 exhibits tumor heterogeneity and is found to be upregulated in specific malignancies, such as breast cancer, thereby promoting oncogenesis (37)

Barry Conrad But we're not endorsing alcoholism or drinking over drinking

It is noteworthy that two Arg residues, Arg140 and Arg172, are thought to be crucial for IDH2 activity because their frequent mutations have been observed in several cancer-associated diseases 4, 5