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Various methods have been described for measuring thiols and disulfides in plasma, but because of the dynamic nature of thio-disulfide exchange reactions, these measurements have remained challenging 6

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The European Medicine Agency (EMA) has recently approved ubiquinolthe reduced form of CoQ 10 (CoQ 10 H 2 )as an orphan drug for the treatment of primary CoQ 10 deficiency ( However, patients suffering from secondary CoQ 10 deficiency may fail to respond to CoQ 10 supplementation (Pineda et al., 2010)

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Gastroenterology referral might be considered to investigate malabsorption disorders such as coeliac disease or Crohn's disease