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When mitochondrial homeostasis is shifted, these pathways become altered or shut down, likely contributing to the death of hepatocytes with activation of inflammation and hepatic stellate cells, causing liver fibrosis and cirrhosis

Diabetes 60 , 24412449 (2011)

Oxid Med Cell Longev 2019(1):2716870 Hussein S et al (2024) Urtica pilulifera leaves extract mitigates cadmium induced hepatotoxicity via modulation of antioxidants, inflammatory markers and Nrf-2 signaling in mice

Moreover, the numerous bioactive compounds found in spirulina have antioxidant potential, neutralizing free radicals and reactive oxygen species, thus reducing oxidative stress and slowing the aging process of the body

Another strategy to achieve early memory phenotypes is the use of pharmacological inhibitors targeting T-cell differentiation signaling pathways during the culture of CAR-T cells, such as phosphatidylinositol 3-kinase (PI3K) inhibitors (duvelisib) and Brutons tyrosine kinase inhibitors (ibrutinib) [62, 63]