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In a PD animal model, tenuigenin significantly improved motor behavior and reduced dopaminergic neuronal damage by inhibiting the NLRP3 inflammasome (Fan et al., 2017)

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through the non-oxidative phase, the synthesis of nucleotides will be supported by the provision of ribose-5-phosphate (to which external ribose can also contribute, if ribokinase is present)

*Correspondence: Igor Allaman, EPFL, SV/ Brain Mind Institute/LNDC, AAB 117, Station 19, CH-1015 Lausanne, Switzerland e-mail: [email protected] This article was submitted to Neuroenergetics, Nutrition and Brain Health, a section of the journal Frontiers in Neuroscience