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Some clinical studies have found that oral supplementation of glutamine can reduce acute radiation toxicity and weight loss, and can also reduce the demand for analgesic drugs in patients with chest and upper respiratory and digestive tract malignancies (NCT05054517) [93], and is helpful in improving vincristine-induced peripheral neuropathy in children with tumors (NCT00365768) [96]

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We then used Fishers r -to- z transformation to test the significance of difference between the correlations, and found that the correlation between glutamate and GSH was significantly weaker in patients compared to the healthy control subjects ( Z = 2.26, p = 0.023) (see Fig