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75(2): 162168.CrossRefGoogle ScholarPubMed Huisman, J, Bosch, J, Waal, HD-V

Hypoxic conditions result in a more aggressive phenotype of cancer cells, likely due to hypoxia-induced changes in gene expression and subsequent proteomic alterations [47]

Although that trial did not reverse pre-neoplastic changes, the reduction in cell proliferation supports further investigation of SFN for lung cancer chemoprevention (129)