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Immunostainable IGF-I has been found in adult human testes[116]

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Abbreviations IBD: Inflammatory bowel disease CD: Crohns disease UC: Ulcerative colitis DSS: Dextran sulfate sodium ALI: Acute lung injury JAK: Janus kinase STAT3: Signal transducer and activator of transcription 3 NF-B: Nuclear factor kappa-b NLRP3: Nod-like receptor pyrin domain-containing 3 NEK7: Nima-related kinase 7 BRD4: Bromodomain-containing protein 4 Wnt: Wingless/integrated signaling pathway TGF-: Transforming growth factor-beta AXL: Axl receptor tyrosine kinase FZD8: Frizzled-8 PIKfyve: Phosphatidylinositol-3-phosphate 5-kinase TLR3: Toll-like receptor 3 TLR4: Toll-like receptor 4 AhR: Aryl hydrocarbon receptor Nrf2: Nuclear factor erythroid 2-related factor 2 AMPK: Amp-activated protein kinase PXR: Pregnane x receptor TNF-: Tumor necrosis factor-alpha IL-1: Interleukin-1 beta IL-6: Interleukin-6 IL-8: Interleukin-8 IL-12: Interleukin-12 IL-17A: Interleukin-17 A IL-23: Interleukin-23 IFN-: Interferon-gamma Th1: T helper 1 cells Th2: T helper 2 cells Th17: T helper 17 cells CD4 T cells: Cluster of differentiation 4 positive t cells ROS: Reactive oxygen species iNOS: Inducible nitric oxide synthase HMGB1: High mobility group box 1 MLKL: Mixed lineage kinase domain-like protein H3K122Ac: Histone h3 lysine 122 acetylation CBP: Creb-binding protein FOXO-1: Forkhead box o 1 COL3A1: Collagen type 3 alpha 1 chain ACTA2: Actin alpha 2 DARTS: Drug affinity responsive target stability IC: Half maximal inhibitory concentration SNX10: Sorting nexin 10 HSP90: Heat shock protein 90 MSU: Monosodium urate DALYs: Disability-adjusted life years HALE: Healthy life expectancy References Zurba Y, Gros B, Shehab M (2023) Exploring the pipeline of novel therapies for inflammatory bowel disease

De asemenea, pot aparea probleme de vedere, cum ar fi sensibilitatea crescuta la lumina, vederea incetosata sau problemele in deosebirea culorii albastru de culoarea verde