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If mild gastrointestinal discomfort occurs, dividing the total daily dose into smaller morning and afternoon portions can significantly improve tolerability while maintaining steady plasma levels

Also, if you are simply not eating enough B12, are young, and have no absorption issues, then oral B12 supplementation may be enough to boost your levels

doi: 10.1016/j.domaniend.2006.01.002 15 Molon-NoblotSLaroquePPrahaladaSStabinskiLGHoeC-MPeterCPet al

Additionally, it exhibits an anti-inflammatory action, reducing pro-inflammatory cytokines such as IL-6, TNF-alpha, and IL-1, while increasing IL-10 and IL-4 in the brain and plasma, and decreasing microglial reactivity [27]

Polyphenols and metabolism: from present knowledge to future challenges