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Screening of drug safety plays a significant role in the process of drug research and development [42,43]

It was shown that STAT5-deficient NK are able to produce increased levels of VEGF-A, suggesting that STAT5 is a repressor of NK-induced angiogenesis [47]

For arthritis specifically, semaglutide has evidence from the STEP-9 knee osteoarthritis trial and studies on rheumatoid arthritis joint outcomes, while tirzepatide has shown roughly a 33% reduction in hsCRP and an 18% reduction in IL-6 (key inflammation markers) in meta-analyses

This is largely due to a lack of isoform specific inhibitors and activators and the need to target specific cells to avoid unintended effects