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The incidence of Cushings syndrome, either exogenously generated due to prolonged use of glucocorticoid therapy or due to endogenous overexpression due to adrenal tumors, is very low and reported to be at approximately 0.7 to 2.4 individuals per million in the general population (Newell-Price et al., 2006)

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Monocytes/macrophages have been found to massively infiltrate synovial membranes 51 and be central to the pathophysiology of inflammation

10.2174/156652409787847209 54 MontuschiP

Discussion Cisplatin, the main chemotherapeutic drug used to treat lung cancer, was the first FDA-approved platinum compound for cancer treatment, in 1978