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( D ) Liver metastatic (PDAC) cell lines stably expressing non-targeting Control, sh Gstt1 or ipCW- Gstt1 in the presence of control shRNA or shRNA targeting FN1 were plated and conditioned media was collected 5 days after dH2O or doxycycline treatment (where indicated)

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The liver is a key target of THs, with THs playing significant roles in liver disease pathogenesis such as alcoholic liver disease and non-alcoholic steatohepatitis [21, 22]

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