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While Lipinskis Rule of Five suggested that molecules with a molecular weight less than 500 Da have better chances of crossing the BBB than larger molecules, its essential to note that Lipinski himself cautioned against applying these rules to certain categories of molecules, such as anti-parasitic drugs

It plays the important role of protecting cells from potential damage by free radicals, formed by peroxide decomposition

Theurl M, Theurl I, Hochegger K, Obrist P, Subramaniam N, van Rooijen N, et al

J Basic Microbiol 62(9):10641082

Several effects in response to exposure to metals, especially those involving gene expression and behavior have been reported using the nematode as a model