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In terms of the occurrence of Hhcy in patients with -TM based on their MTHFR genotypes, the data show a significant and clear connection between Hhcy and possession of the MTHFR TT genotype, with all patients with the TT genotype (100%) being assessed hyperhomocystinemic (15 mol/l) compared to those with CT (40%) or CC genotypes (29%) P (Fig

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In addition to this, alcohol abuse is considered a chronic disease that promotes the pathogenesis of many fatal diseases, such as cancer and liver cirrhosis (due to decreased hepatic storage vitamin B12 deficiency can develop quickly in chronic liver illness)

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