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Also, the framework assumes steady-state metabolism and constant photon input, thereby limiting its ability to represent dynamic temporal metabolic reprogramming

this is where prototyping and tracer code comes in handy

Methods Enzymol 186:421431 Duan W, Lee J, Guo Z, Mattson MP (2001) Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury