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If DNA synthesis and/or methylation (epigenetic events) are altered in utero, this could affect gene expression thus impacting fetal development and that could modulate the fetal susceptibility to various diseases

Neurogenic bladder dysfunction refers to any disturbance of bladder function due to impaired neural control and needs to be distinguished from non-neurogenic bladder disorders, especially in elderly individuals

It can take up to 5 years before a deficiency manifests itself clinically, and NPs should be aware and alert to the possibility of B12 deficiency in their patients on prolonged metformin