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Daratumumab in combination with lenalidomide plus dexamethasone induces clonality increase and t-cell expansion: results from a phase 3 randomized study (POLLUX)

Observations from research literature are presented for experimental context only and do not imply approved human or animal use

doi:10.2174/157340313805076322 Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R

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However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007