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Figure 2 2.1.3 Iron metabolism and ferroptosis Iron is an essential trace element in the human body, playing multiple important biological roles, including inducing ATP production, participating in DNA and hemoglobin synthesis, and many other physiological activities ( Fe 3+ ions are reduced to Fe 2+ ions and then transported and stored in the cellular iron pool, while excess Fe 2+ ions are stored in ferritin ( 2+ ions, inducing the production and accumulation of large amounts of ROS through the Fenton reaction, ultimately promoting cell ferroptosis ( TFRC is the gene encoding the transferrin receptor

Pro-angiogenic substances stimulate the development of new blood vessels in joints, a process known as joint neovascularization (angiogenesis), and this process is essential for the maintenance and advancement of synovitis in RA [35]

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