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These in vitro results have been further validated in murine models of malaria infection and rheumatoid arthritis, where G6PD-d or inhibition leads to less severe proinflammatory responses to stimulation marked by reduced Th1 and Th17 differentiation, decreased proatherogenic cytokines IL-1, IL-6, IL-12, and TNF, and no impact on IL-10 and TGF (classically Treg-derived) 120,121,122,123,124

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In hypoxic settings, erythropoiesis is meticulously regulated by the activation of the hypoxia-inducible factor (HIF) pathway, which largely enhances erythropoietin (EPO) synthesis in renal peritubular cells (53)