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Although immunogenicity to biologics is often not directly associated with adverse events in animal models, these studies have limited predictive power for the immunogenicity of the biologic in humans

Emerging studies on the molecular mechanisms of Ewing sarcoma hold promise for improvements in early detection, disease monitoring, lower treatment-related toxicity, overall survival and quality of life

The more sophisticated design makes use of multiple signals in the infection microenvironment

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In addition to TJs, interendothelial gap also features adherens junctions (AJs) and related proteins functioning as junctional complexes, which are involved in the maintenance of BBB permeability, cell adhesion and angiogenesis (24)