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Nirenberg et al., 1997a)

With increasing age, the melatonin levels tend to decrease due to reduced secretion, which may cause difficulty in sleep regulation

The first nootropic to use the term was a drug developed in the 1960s called piracetam.60 61 It was intended to treat anxiety and provide patients with a soothing experience that might even lull them to sleep.2 The effect was quite different than what its creators intended, as users reported sharper focus, and later testing pointed toward improved memory

Beta-2 microglobulin (B2M) served as the endogenous reference gene for normalization

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data 3