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They act as irreversible EGFR inhibitors, effectively managing cancer progression induced by EGFR-TKI-sensitive and T790M-resistant mutations, with an added advantage of controlling brain metastases (Remon and Planchard, 2015

Sanyal AJ, Loomba R, Anstee QM, Ratziu V, Kowdley KV, Rinella ME, Harrison SA, Resnick MB, Capozza T, Sawhney S, Shelat N, Younossi ZM

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