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306 Moreover, SIRT6 is termed a DSB sensor due to its sensitivity to DNA repair, which is important for longevity and cancer prevention

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To induce the depletion and impotence of effector T cells, the peripheral cells, CAFs and MDSCs, and T cells can be induced to express immunoglobulin and PDL1 on their surfaces, and secret related factors such as IDO and TGF- (72)

These observations highlight the need for large-scale, multicenter, randomized, placebo-controlled trials to ascertain whether targeted modulation of specific probiotic strains or other gut microbes associated with a lean phenotype can effectively counteract obesity and improve insulin sensitivity