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10.1016/j.brainresbull.2020.08.019 42 KirchingerM.BielerL.TeviniJ.VoglM.Haschke-BecherE.FelderT

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It was initially obtained from the extract of oak gall and is a natural secondary metabolite mainly extracted from various fruits, plants and nuts (Wianowska et al., 2023)

Beyond their established use in sleep disorders, ramelteon alleviates experimental acute ocular inflammation via HIF-1/VEGF/E-NOS signaling (Usta Sofu et al., 2022), while agomelatine attenuates cisplatin-induced nephrotoxicity by suppressing NF-B-driven inflammation ( These advances are supported by systematic pharmacological reviews from our team and others (Ruan et al., 2021